Postdoctoral Associate - Stanley Center

Broad Institute
United States, Massachusetts, Cambridge
Oct 15, 2025
Description & Requirements We are looking for a highly motivated Junior Postdoctoral Associate to join a dynamic team investigating the physiology of thalamic circuits in animal models of psychiatric disorders. The candidate is expected to have experience in vivo electrophysiology including local field potential (LFP), single-unit, and multi-unit recordings, to study how thalamocortical dysfunction contributes to sensory, attentional, cognitive and other behavioral abnormalities. The position provides an opportunity to integrate these approaches with complementary in vivo imaging techniques (e.g. calcium imaging, GRAB sensors, functional ultrasound, or fMRI) and advanced data analysis to achieve a systems-level understanding of brain circuit function. The Stanley Center and the Broad Institute provide a vibrant research environment with close links to MIT, Harvard and the Harvard-affiliated hospitals across Boston. Being a member of our team will provide the opportunity for your contributions to be utilized and recognized across the vast global network of researchers in the fields of genomics and psychiatric disease research. CHARACTERISTIC DUTIES Perform in vivo electrophysiology recordings in rodent models, including LFP, single-unit, and multi-unit recordings, in thalamus and connected circuits of rodent models. Implement optogenetic or chemogenetic manipulations to dissect circuit-specific mechanisms. Analyze neural activity using advanced data processing approaches such as spike sorting, spectral analysis, connectivity metrics and state-space modeling. Collaborate with team members to integrate electrophysiological findings with in vivo imaging methods including calcium imaging, functional ultrasound (fUS), and fMRI. Rodent colony maintenance and handling. Prepare manuscripts and present findings at conferences. Provide mentorship and training for graduate students, technicians, or junior researchers. QUALIFICATIONS* Ph.D. in neurobiology, neuroscience, biomedical engineering, or a related field. Prior lab experience in in vivo electrophysiology (LFP, single-unit, multi-unit recordings). Must be comfortable working with animals. Proficiency in at least one scientific programming language (e.g., Python, MATLAB, R) for data analysis. Outstanding personal initiative and communication skills, and be able to work in a team. Exceptional organizational and time management skills, lab notebook practices and attention to detail.