Sr. Scientist, Protein Engineering

10x Genomics Inc
United States, California, Pleasanton
6230 Stoneridge Mall Road (Show on map)
Oct 15, 2025
About the role: We are seeking an outstanding dual-skilled Protein Engineer to join the Protein Engineering team at 10x Genomics. This key role drives the computational design and experimental validation of novel proteins and enzymes critical for building 10x's strongly differentiated portfolio of capabilities. The ideal candidate possesses deep expertise across the entire Design-Build-Test cycle with proven mastery of computational tools used for protein structure modeling, demonstrated wet lab execution, and proven impact in solving complex biological problems What you will be doing: You will join the Protein Engineering group within the Spatial Biology Department at 10x Genomics. Your peers will be enzymologists and protein biochemists with extensive molecular biology expertise. You will be collaborating with scientists and computational biologists working on multiple internal development projects across the product portfolio. You will: Develop structural/computational biology workflows and/or machine learning methods to analyze existing, and design new, biomolecular structures Develop analytical and enzymatic assays to test your constructs and inform future development Apply Design of Experiments (DoE) principles to guide the optimization of enzyme reaction conditions Contribute to innovation and to building the company's strong IP portfolio Collaborate with scientists and computational biologists working on multiple internal development projects across the product portfolio To be successful in this role, you will need: PhD or Masters in chemistry, biochemistry, computer science, physics or related fields with a minimum of 2 year's post-graduate experience Experience with macromolecular modeling is required. Proven proficiency in key computational tools, including AlphaFold (structure prediction), ProteinMPNN and RFdiffusion (inverse/de novo design), PyMOL and Foldseek (structural analysis). Experience in modeling protein:nucleic acid complexes is desired. Experience with interfacing with, curating, and extracting information from sequence/protein databases is highly desired Strong data analysis skills. Scripting in Python and/or R is strongly desired Demonstrated wet lab experience and design in molecular cloning, protein expression/purification, and developing/executing analytical and functional assays to rigorously test design hypotheses Demonstrated track record in using directed evolution or rational design to enhance function and solve complex biological problems, with a broad understanding of protein design applications in genomics is highly desired Excellent communication and organizational skills to manage multidisciplinary projects Desire to build game-changing technologies and impact the world of life science research Below is the base pay range for this full-time position. The actual base pay will depend on several factors unique to each candidate, including one's skills, qualifications, and experience. At 10x, base pay is also just one component of the Company's total compensation package. This role is also eligible for 10x's equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program. During the hiring process, your 10x recruiter can share more about the Company's total compensation package. Pay Range $153,100 — $207,100 USD About 10x Genomics At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world. We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience. Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference. Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation,or any other characteristic protected by applicable law. 10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.