New

Scientist 2 - Research and Development

Ampcus, Inc
United States, New Jersey, Titusville
Oct 16, 2025
Ampcus Inc. is a certified global provider of a broad range of Technology and Business consulting services. We are in search of a highly motivated candidate to join our talented Team. Job Title: Scientist 2 - Research and Development Location: Titusville, NJ (Onsite) Job Responsibilities: 30% - Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects. 20% - Optimize methods and improve analytical capabilities for Client Oligonucleotide synthesis. 10% - Analyze and optimize methods in a project-specific way (i.e., GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS. 20% - Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput. 5% - Analyze oligonucleotides by HPLC-SEC, RP-IP, and Ion-Exchange Chromatography. Continue optimizing siRNAs using best-in-class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization. Support integrity confirmation requests (such as concentration) by assay development and biology teams. 3% - Conduct QC for lipid nanoparticle (LNP) formulations of mRNA. 5% - Ensure the supply of laboratory consumables and reagents are in stock as needed. Maintain a high level of productivity in the laboratory setting. 2% - Present data and reports on project status at individual, group, and departmental meetings. Educational Qualifications: Ph.D. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required. Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required. Preferred Skillset: Operate LC-MS systems Analyze and optimize methods Establish and automate high throughput analytical capabilities. Ampcus is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veterans or individuals with disabilities.