Mass Spectrometry Based Multi-Omics Research Scientist

As a solutions-based company, Precise Systems is focused on innovation in support of the warfighters and aligning our expertise to deliver the highest quality of service. Powered by our highly skilled workforces, we provide expert consultation on network and weapons systems acquisition programs, maintenance/modernization programs, and sustainment programs with solutions in Digital Transformation, Advanced Engineering, Physical Sciences Research, Platform Lifecycle Support, and Technical Services. Since our establishment, we have demonstrated and perfected our ability to manage the customer's needs, no matter how complex - offering exceptional service and the Precise solution.

Precise Systems seeks a Multi-Omics Scientist to develop, optimize and implement MS methods to detect and quantify known, unknown, and emerging infectious human disease pathogens. DEVCOM Chemical Biological Center (CBC) is the primary Department of Defense technical organization for non-medical chemical and biological defense.

All work is performed on site, in Edgewood, MD, 5 days per week. Remote delivery is not authorized.

Duties:

• Collaborate with a team to design, test, and deliver liquid chromatography coupled with mass spectrometry (LC-MS) methods to detect proteins, metabolites and lipids.
• Develop detection methods in the laboratory, optimize and streamline them for field use, troubleshoot processes and equipment, train and prepare for field demonstrations.
• Curate unique methods to extract both metabolites and lipids from simple and complex mediums such as cell lysates, tissues, bacteria, hair, soil, and other environmental substrates/surfaces.
• Execute standard biophysical techniques for bottom-up proteomics including protein quantification, protein extraction/isolation, reduction, alkylation, enzymatic digestion, peptide quantification, and peptide concentration normalization.
• Validate and optimize metabolomics and lipidomics workflows for MS analysis including sample preparation techniques like BAW, Bligh-Dyer, MTBE, and Matyash extraction methods.
• Analyze data generated from multi-omics experimentation including database sequence searching, algorithm etic interpretation of the data sets, and visualization.
• Perform metabolite purification and quantification procedures such, solid phase extraction, and C18 clean up strategies followed by a Dansylation assay and metabolite concentration normalization.
• Utilize portable and high-resolution mass spectrometers namely, Thermo Eclipse, Bruker timsTOF Ultra 2, Bruker timsTOF HT, and Agilent QQQ
• Utilize other platforms to support MS acquisition including an Evosep LC, Thermo Ultimate, LC, and Thermo Vanquish LC.
• Develop workflows, optimize and streamline for use in field environments, and troubleshoot processes and equipment to train and prepare for field demonstrations
• Typical samples could be simple or complex, individual or pooled, and require targeted and untargeted approaches.
• Samples may be of human origin or BSL2 near neighbor, simulant, or surrogate pathogens of military relevance
• The laboratory is well supported, with unique capabilities, and opportunities for publication and presentations.

Required Education:

• PhD in Biochemistry, Chemistry, Biology, Molecular Biology or a related field.

Required Experience:

• 5 years' experience in standard mass spectrometric methods for the analysis an detection of small molecules, metabolites, lipids, proteins/peptides,

Desired:

• Extensive experience in MS based multi-omics strategies as well as data analysis.

Must be able to obtain and maintain a Secret security clearance. Due to the sensitivity of customer-related requirements, U.S. Citizenship is required.

Precise Systems values employee contributions, promotes diverse opportunities for professional growth, and prioritizes overall well-being. Our comprehensive professional services benefits package includes health insurance, life and accidental death and dismemberment coverage, disability insurance, retirement plans, holiday pay, employee-managed leave, and professional growth opportunities.

We recognize exceptional performance and alignment with our core values through our STAR Award recognition program.

Compensation at Precise Systems is determined by various factors, including education, experience, skills, competencies, and contract-specific requirements. The salary range for this position is $89,190.40 to $129,298.10 (annualized USD). This range represents the standard pay for this role and is just one component of Precise Systems' total compensation package.

Precise Systems is committed to fair and equitable pay practices in alignment with applicable pay transparency laws and equal employment opportunity standards.

Precise Systems is dedicated to a shared vision and core values of Integrity, Respect, and Responsibility, which foster innovation and drive our continued success in the global marketplace. Precise Systems and its subsidiaries are Equal Opportunity /Affirmative Action Employers. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, protected veteran status, status as an individual with a disability, or any legally protected status under federal, state, or local law. Visit www.GoPrecise.com for a listing of current openings and our comprehensive, employee friendly benefits summary. Precise Systems participates in E-Verify.