Vice President, Pipeline Delivery Systems & Process Enablement

Pipeline Delivery Systems & Process Enablement is a strategic leadership role responsible for building and scaling a seamless, integrated ecosystem of systems, data, and operational processes that enable efficient and predictable delivery of Alnylam's development pipeline.

This leader will drive operational excellence across Clinical Operations, Data Management, and Program Management, ensuring that systems and processes are standardized, user-centric, and enable real-time, data-driven decision-making. Through strong leadership in process design, training, and change management, this role ensures consistent adoption and sustained performance, accelerating the delivery of RNAi therapeutics to patients.

Key Responsibilities

Systems & Digital Enablement Strategy

• Define and execute the Pipeline Delivery systems and data strategy, aligned to R&D priorities and the futurestate operating model, including oversight of integrated clinical and operational platforms.
• Partner with IT and Digital to deliver scalable, usercentric solutions and a single source of truth, enabling speed, quality, transparency, and informed program and portfolio decisionmaking.

Process Excellence & Standardization

• Design, implement, and continuously improve end-to-end processes across study start-up, execution, data flow, and reporting ensuring processes are aligned with regulatory requirements and inspection readiness expectations.
• Drive standardization of workflows, templates, and best practices across Pipeline Delivery functions, simplifying complexity by eliminating redundant or low-value processes.

Operational Performance & Continuous Improvement

• Partner with Portfolio Management to establish a performance management framework (KPIs, metrics, dashboards) to monitor process effectiveness and system utilization.
• Identify and address operational bottlenecks, inefficiencies, and variability.
• Lead continuous improvement initiatives to enhance cycle times, data quality, and execution predictability.
• Embed a culture of operational discipline and continuous learning.

Training & Capability Building

• Develop and implement a comprehensive training strategy aligned to systems, processes, and ways of working.
• Ensure role-based training enables teams to operate effectively within the Pipeline Delivery model.
• Build capability in data literacy, system utilization, and process adherence.
• Continuously evaluate and evolve training approaches to drive effectiveness and engagement.

Change Management & Adoption

• Lead enterprise change management to drive adoption of new systems, processes, and operating models, using structured approaches to stakeholder engagement, communication, and behavior change.
• Champion user experience and organizational readiness, ensuring changes are implemented with minimal disruption and sustained adoption over time.

Cross-Functional Integration

• Serve as a key integrator across Clinical Operations, Data Management, Program Management, and broader R&D functions and partner closely with Portfolio Management to ensure systems support planning, governance, and performance tracking.
• Ensure systems and processes enable seamless handoffs, clear ownership, and aligned execution.
• Align with Vendor & Alliance Management to ensure external partners operate within defined systems and processes.

Organizational Leadership

• Build and lead a high-performing Systems & Process Enablement organization fostering a a culture of innovation, accountability, and continuous improvement.
• Define roles, capabilities, and structure required to support a scalable Pipeline Delivery model.
• Develop talent and ensure strong succession planning.

Key Success Metrics

• Enterprise adoption and impact: Effective utilization of systems and standardized processes across Pipeline Delivery, driving compliance, improved data quality, and faster, more informed decisionmaking.
• Operational performance and transformation success: Reduced cycle times and inefficiencies through strong training effectiveness, user proficiency, and successful delivery and sustained adoption of transformation initiatives.

Qualifications

• BS/MS in Life Sciences, Engineering, Information Systems, Business, or a related field.
• 20+ years of experience in biotech/pharma, with leadership roles in clinical systems, operations, process excellence, or digital enablement.
• Demonstrated experience operating at the enterprise or portfolio level, supporting complex, multi program clinical pipelines.
• Proven track record implementing enterprise systems and process transformations in R&D or Clinical Development (e.g., CTMS, eTMF, data platforms, reporting and analytics).
• Experience driving large-scale change management and adoption initiatives.
• Experience partnering closely with IT, Digital, and Data organizations to deliver scalable, usercentric solutions.
• Expertise establishing performance management frameworks, including KPIs, dashboards, and operational metrics to support portfolio and program decisionmaking.
• Strong continuous improvement mindset, with experience leading initiatives that improve cycle times, data quality, and execution predictability.
• Strong understanding of clinical development processes, data flows, and regulatory requirements.
• Strong capability in organizational change management, including stakeholder engagement, communication planning, and adoption measurement.

U.S. Pay Range

$301,800.00 - $408,200.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.